Variant position: 874 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1186 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LAYLLGSDYTEGIPTVGCVT AMEILNEFPGHGLEPLLKFSE
Mouse LAYLLGSDYTEGIPTVGCVT AMEILNEFPGRGLDPLLKFSE
Xenopus laevis LAYLLGSDYTEGIPTVGYVS AMEILNEFPGQGLEPLVKFKE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1186 DNA excision repair protein ERCC-5
786 – 881 I-domain
848 – 880 DNA-binding; H2TH (helix-2turn-helix) motif which binds double-stranded DNA
861 – 861 Magnesium 2
233 – 1186 Missing. In isoform 3.
871 – 880
Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients.
Emmert S.; Slor H.; Busch D.B.; Batko S.; Albert R.B.; Coleman D.; Khan S.G.; Abu-Libdeh B.; DiGiovanna J.J.; Cunningham B.B.; Lee M.M.; Crollick J.; Inui H.; Ueda T.; Hedayati M.; Grossman L.; Shahlavi T.; Cleaver J.E.; Kraemer K.H.;
J. Invest. Dermatol. 118:972-982(2002)
Cited for: VARIANT XP-G THR-874;
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