Variant position: 266 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 351 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DEELETRAHRVATEERGRKP HQIPASTP--QNPATSQHPPPP------P
Mouse DEELEIKASRTSTVERGPKP HSTPAAAA--QNSVALQAPPP
Rat GEELEIKASRMSTVERGPKP HSTQASAPASQNPVASQAPPP
Horse DEELEIRAHKVISEERGRKP HQIPGSTP--LNPAASQPPPP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 351 T-cell surface antigen CD2
236 – 351 Cytoplasmic
Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.
Seed B.; Aruffo A.;
Proc. Natl. Acad. Sci. U.S.A. 84:3365-3369(1987)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLN-266; SUBCELLULAR LOCATION;
The structure of the human CD2 gene and its expression in transgenic mice.
Lang G.; Wotton D.; Owen M.J.; Sewell W.A.; Brown M.H.; Mason D.Y.; Crumpton M.J.; Kioussis D.;
EMBO J. 7:1675-1682(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT GLN-266;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT GLN-266;
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