Variant position: 110 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 131 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GLQPLPQTSHH--HRHHRAAAT NPARYCCLSGCTQQDLLTLCP
Chimpanzee GLQPLPQTSHH--HRHHRAAAT NPARYCCLSGCTQQDLLTL
Mouse ------QLPRQASQRQRRSAAT NAVHRCCLTGCTQQDLLGL
Rat DPALDPQLPHQASQRQRRSVAT NAVHRCCLTGCTQQDLLGL
Pig APQPPPQASGH--HHHRRAAAT NPARHCCLSGCTRQDLLTL
Bovine APQPLPQASRH--HHHRRATAI NPARHCCLSGCTRQDLLTL
Drosophila -------------TRRLRDGVF DE---CCLKSCTMDEVLRY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
106 – 131 Insulin-like 3 A chain
34 – 116 Interchain (between B and A chains)
46 – 129 Interchain (between B and A chains)
64 – 131 RELLQWLERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY -> QRESHSVSQAGLKLLSSSNPPTLTFQSVGISDVSCYSGWRDDICSMGWWPTVISRWDLACSPCPRPLTITATTVQLPPTLHATAASVAVPNKTC. In isoform 2.
A novel mutation of the insulin-like 3 gene in patients with cryptorchidism.
Canto P.; Escudero I.; Soederlund D.; Nishimura E.; Carranza-Lira S.; Gutierrez J.; Nava A.; Mendez J.P.;
J. Hum. Genet. 48:86-90(2003)
Cited for: VARIANT CRYPTO LYS-110;
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