Variant position: 1157 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2602 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VASGPGLEHGKVGEAGLLSV DCSEAGPGALGLEAVSDSGTK
Mouse VASGPGLEHGKVGEPGILCV DCSEAGPGTLGLEAVSDSGAK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha.
Takafuta T.; Wu G.; Murphy G.F.; Shapiro S.S.;
J. Biol. Chem. 273:17531-17538(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; SUBCELLULAR LOCATION; INTERACTION WITH GP1BA; VARIANTS ASN-1157 AND MET-1471;
Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.
Chakarova C.; Wehnert M.S.; Uhl K.; Sakthivel S.; Vosberg H.-P.; van der Ven P.F.M.; Fuerst D.O.;
Hum. Genet. 107:597-611(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1); GENE ORGANIZATION; SIMILARITY TO OTHER MEMBERS OF THE FAMILY; VARIANTS ASN-1157 AND MET-1471;
Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method.
Oshikawa M.; Sugai Y.; Usami R.; Ohtoko K.; Toyama S.; Kato S.;
DNA Res. 15:123-136(2008)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 8 AND 9); VARIANTS ASN-1157 AND MET-1471;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.