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UniProtKB/Swiss-Prot Q13618: Variant p.Asp13His

Cullin-3
Gene: CUL3
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Variant information Variant position: help 13
Type of variant: help LB/B
Residue change: help From Aspartate (D) to Histidine (H) at position 13 (D13H, p.Asp13His).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and polar (H)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 13
Protein sequence length: help 768
Location on the sequence: help MSNLSKGTGSRK D TKMRIRAFPMTMDEKYVNSI
Residue conservation: help 
Human                         MSNLSKGTGSRKDTKMRIR-AFPMTM--DEKYVNSI

Mouse                         MSNLSKGTGSRKDTKMRIR-AFPMTM--DEKYV

Rat                           MSNLSKGTGSRKDTKMRIR-AFPMTM--DEKYV

Xenopus tropicalis            MSNLGKSTGSRKDTKMRIR-AFPMTM--DEKYV

Caenorhabditis elegans        ---MSGRSGNGGQQKMRIR-PFMATI--DEQYV

Slime mold                    -------MMAKPNGKIQFKNLQSHGVLADPDFP

Baker's yeast                 ---------MITNKKIKISVPEKLGL--SEESF

Fission yeast                 ---------MQRSAKLKIRAPRKFSA--NQVDF
Sequence annotation in neighborhood: help
TypePositionsDescription
Initiator methionine 1 – 1 Removed
Chain 2 – 768 Cullin-3
Region 2 – 41 Interaction with KLHL18
Modified residue 2 – 2 N-acetylserine
Alternative sequence 1 – 24 Missing. In isoform 2.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.