Variant position: 357 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 639 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TTPLASAPRPAAPANNPPPP SLMSTTQSRPPWMNSGPSESR
Mouse TTPLASAPRPAAPASNPPPP SLMSTTQSRPPWMNSGPSENR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 639 Splicing factor 1
325 – 639 Disordered
346 – 361 Pro residues
Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA.
Arning S.; Grueter P.; Bilbe G.; Kraemer A.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); PROTEIN SEQUENCE OF 20-30 AND 136-150; VARIANT THR-357; FUNCTION; INTERACTION WITH U1 SNRNA; RNA-BINDING;
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