Variant position: 19 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 144 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MYSEIQRERADIGGLMAR PEYREWNPELIKPKKLLNPVK
Chimpanzee MYSEIQRGRADIGGLMAR PEYREWNPELIKPKKLLNPVK
Mouse MYSEIQRERADIEGLMAR PEYREWNSELIKPKKLLNPVK
Rat -------------MARAG PEYREWNSELIKPKKLLNPVK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 144 Actin-associated protein FAM107A
1 – 1 M -> MAQRLGEWARGPSDATGLYRAVLLRSAAM. In isoform 3.
1 – 1 M -> MGAAQGKKKTYSPQARFHSENEKQRRNGSAAM. In isoform 4.
Loss of expression of the DRR1 gene at chromosomal segment 3p21.1 in renal cell carcinoma.
Wang L.; Darling J.; Zhang J.-S.; Liu W.; Qian J.; Bostwick D.; Hartmann L.; Jenkins R.; Bardenhauer W.; Schutte J.; Opalka B.; Smith D.I.;
Genes Chromosomes Cancer 27:1-10(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; VARIANTS MET-15 AND LEU-19;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.