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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P55265: Variant p.Lys384Arg

Double-stranded RNA-specific adenosine deaminase
Gene: ADAR
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Variant information Variant position: help 384
Type of variant: help LB/B
Residue change: help From Lysine (K) to Arginine (R) at position 384 (K384R, p.Lys384Arg).
Physico-chemical properties: help Similar physico-chemical property. Both residues are large size and basic.
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 384
Protein sequence length: help 1226
Location on the sequence: help QIKRNTNSVPETAPAAIPET K RNAEFLTCNIPTSNASNNMV
Residue conservation: help 
Human                         QIKRNTNSVPETAPAAIPETKRNAEFLTCNIPTSNASNNMV

Mouse                         QMKRSTHSAPAPTPTAVPEATRSPSFPACHPPPAGASSSVA

Rat                           QMKRSTHSGPAATPAAVSEATQSTSFPTCHPPQSGGSSSMA

Caenorhabditis elegans        DLD--------------------------------------
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 1226 Double-stranded RNA-specific adenosine deaminase
Cross 384 – 384 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)



Literature citations
Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.
Patterson J.B.; Samuel C.E.;
Mol. Cell. Biol. 15:5376-5388(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; CATALYTIC ACTIVITY; SUBCELLULAR LOCATION; INDUCTION BY INTERFERON; VARIANTS GLY-100 AND ARG-384; Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase.
Liu Y.; George C.X.; Patterson J.B.; Samuel C.E.;
J. Biol. Chem. 272:4419-4428(1997)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3); VARIANTS GLY-100 AND ARG-384; The gene coding for the interferon-inducible human dsRNA adenosine deaminase is transcribed into several messengers specifying different proteins.
Deblandre G.; Marinx O.; Nols C.; Defrance P.; Berr P.; Huez G.; Caput D.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5); VARIANTS GLY-100 AND ARG-384; The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4); VARIANTS GLY-100 AND ARG-384;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.