Sequence information
Variant position: 142 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 359 The length of the canonical sequence.
Location on the sequence:
QLETSLKRLQCPQVDLFYLH
A PDHGTPVEETLHACQRLHQE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QLETSLKRLQCPQVDLFYLHA PDHGTPVEETLHACQRLHQE
Mouse QLETSLKRLQCPRVDLFYLHA PDHSTPVEETLRACHQLHQE
Rat QLETSLKRLQCPRVDLFYLHA PDHGTPIVETLQACQQLHQE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 359
Aflatoxin B1 aldehyde reductase member 2
Binding site
141 – 141
Substrate
Modified residue
128 – 128
N6-acetyllysine
Literature citations
Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.
Ireland L.S.; Harrison D.J.; Neal G.E.; Hayes J.D.;
Biochem. J. 332:21-34(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-359; PARTIAL PROTEIN SEQUENCE; FUNCTION; SUBUNIT; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; VARIANT THR-142;
Genetic variation of aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.
Praml C.; Schulz W.; Claas A.; Mollenhauer J.; Poustka A.; Ackermann R.; Schwab M.; Henrich K.-O.;
Cancer Lett. 272:160-166(2008)
Cited for: VARIANTS THR-142 AND HIS-157;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.