Variant position: 1165 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1226 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TV---DGPRNEL---SRVSKKNIFLL FKKLCSFRYRRDLLRLSYGEA
Mouse TV---DGPGKEL---SRVSKKNIFLQ FKKLCSFRARRDLLQ
Rat TV---DGPGKEL---SRVSKKNIFLQ FKKLCSFRARRDLLQ
Caenorhabditis elegans MVHDKDMSGADITTPSRLCKKNMAEL MITICTLTKTSVDYP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1226 Double-stranded RNA-specific adenosine deaminase
886 – 1221 A to I editase
Mutations of the RNA-specific adenosine deaminase gene (DSRAD) are involved in dyschromatosis symmetrica hereditaria.
Miyamura Y.; Suzuki T.; Kono M.; Inagaki K.; Ito S.; Suzuki N.; Tomita Y.;
Am. J. Hum. Genet. 73:693-699(2003)
Cited for: VARIANTS DSH PRO-923 AND SER-1165;
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