Variant position: 505 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 707 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VWDIETGQCLHVLMGHVAAV RCVQYDGRRVVSGAYDFMVKV
Mouse VWDIETGQCLHVLMGHVAAV RCVQYDGRRVVSGAYDFMVKV
Rat VWDIETGQCLHVLMGHVAAV RCVQYDGRRVVSGAYDFMVKV
Bovine VWDIETGQCLHVLMGHVAAV RCVQYDGRRVVSGAYDFMVKV
Drosophila VWDIEQGSCLHVLVGHLAAV RCVQYDGKLIVSGAYDYMVKI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.
Moberg K.H.; Bell D.W.; Wahrer D.C.R.; Haber D.A.; Hariharan I.K.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANTS CYS-465 AND LEU-505;
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-465; LEU-505 AND LEU-582;
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