Variant position: 366 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 394 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LRISTASGDGRHYCYPHFTC AVDTENIRRVFNDCRDIIQRM
Mouse LRISTASGDGRHYCYPHFTC AVDTENIRRVFNDCRDIIQRM
Rat LRISTASGDGRHYCYPHFTC AVDTENIRRVFNDCRDIIQRM
Bovine LRISTASGDGRHYCYPHFTC AVDTENIRRVFNDCRDIIQRM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 394 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
39 – 394 G-alpha
364 – 369 G5 motif
366 – 366 GTP; via amide nitrogen
352 – 352 Phosphoserine
365 – 367
Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function.
Iiri T.; Herzmark P.; Nakamoto J.M.; van Dop C.; Bourne H.R.;
Cited for: CHARACTERIZATION OF VARIANT PHP1A SER-366;
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