Variant position: 296 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 333 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KIGVMVCVGIMAACPSGHAA ILISGNAKLRRAVMTILLWAQ
Gorilla KIGVMVCVGIMAACPSGHAA VLISGNAKLRRAVTTILLWAQ
Chimpanzee KIGVMVCVGIMAACPSGHAA VLISGNAKLRRAVTTILLWAQ
Mouse KGGVMICIGMMAACPSGHAA ILISGNAKLRRAIETMLFWFQ
Rat KGGVMVCIGMMAACPSGHAA ILISGNAKLKKVIVTILFWFQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 333 Taste receptor type 2 member 38
277 – 297 Helical; Name=7
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.
Kim U.-K.; Jorgenson E.; Coon H.; Leppert M.; Risch N.; Drayna D.T.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS PRO-49 AND VAL-296;
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