Variant position: 142 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 488 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FGAM------------------VATMFCWVTAMQFHLM FYCTRTLPN-VLALPVVLLALA
Mouse FGAT------------------VAVMFCWISATQFHLM FYC
Caenorhabditis elegans FGRE------------------TAMYLRLIMCTQFHYI FYM
Drosophila YGVE------------------VRLWFTAITITQFHFM FYM
Baker's yeast FDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLM FYS
Fission yeast FGTL------------------SGALFILFSCAQFHLV YYM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 488 Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
122 – 142 Helical
Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase.
Chantret I.; Dupre T.; Delenda C.; Bucher S.; Dancourt J.; Barnier A.; Charollais A.; Heron D.; Bader-Meunier B.; Danos O.; Seta N.; Durand G.; Oriol R.; Codogno P.; Moore S.E.H.;
J. Biol. Chem. 277:25815-25822(2002)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT CDG1G VAL-142;
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