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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q8IUX4: Variant p.Val231Ile

DNA dC->dU-editing enzyme APOBEC-3F
Gene: APOBEC3F
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Variant information Variant position: help 231
Type of variant: help LB/B
Residue change: help From Valine (V) to Isoleucine (I) at position 231 (V231I, p.Val231Ile).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 3
Other resources: help


Sequence information Variant position: help 231
Protein sequence length: help 373
Location on the sequence: help YGRNESWLCFTMEVVKHHSP V SWKRGVFRNQVDPETHCHAE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 373 DNA dC->dU-editing enzyme APOBEC-3F
Domain 174 – 321 CMP/dCMP-type deaminase 2
Active site 251 – 251 Proton donor
Binding site 249 – 249
Cross 234 – 234 (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Alternative sequence 80 – 373 Missing. In isoform 2.
Alternative sequence 114 – 373 Missing. In isoform 3.
Mutagenesis 249 – 249 H -> C. Reduced but not abolished antiviral activity.
Mutagenesis 249 – 249 H -> R. Nearly abolished antiviral activity; when associated with R-65.
Mutagenesis 251 – 251 E -> A. Decrease in cytidine deaminase and antiviral activity.
Mutagenesis 251 – 251 E -> A. Decrease in cytidine deaminase and antiviral activity; when associated with A-67.
Mutagenesis 251 – 251 E -> Q. Remains able to bind Vif.
Mutagenesis 251 – 251 Missing. Reduced but not abolished antiviral activity. Nearly abolished antiviral activity; when associated with Q-67.



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS THR-178; ILE-231 AND CYS-307;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.