UniProtKB/Swiss-Prot Q8IUX4: Variant p.Val231Ile

• Variant information
• Sequence information
• Literature citations
• All

Variant information

Variant position: 231 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: LB/B The variants are classified into three categories: LP/P, LB/B and US.

• LP/P: likely pathogenic or pathogenic.
• LB/B: likely benign or benign.
• US: uncertain significance

Residue change: From Valine (V) to Isoleucine (I) at position 231 (V231I, p.Val231Ile). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: Similar physico-chemical property. Both residues are medium size and hydrophobic. The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: 3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

• Lowest score: -4 (low probability of substitution).
• Highest score: 11 (high probability of substitution).

More information can be found on the following page
Other resources: Links to websites of interest for the variant.

• Variant rs2076101 [ dbSNP | Ensembl ]

Sequence information

Variant position: 231 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 373 The length of the canonical sequence.
Location on the sequence: YGRNESWLCFTMEVVKHHSP V SWKRGVFRNQVDPETHCHAE The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

• Type: the type of sequence feature.
• Positions: endpoints of the sequence feature.
• Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 373	DNA dC->dU-editing enzyme APOBEC-3F
Domain	174 – 321	CMP/dCMP-type deaminase 2
Active site	251 – 251	Proton donor
Binding site	249 – 249
Cross	234 – 234	(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Alternative sequence	80 – 373	Missing. In isoform 2.
Alternative sequence	114 – 373	Missing. In isoform 3.
Mutagenesis	249 – 249	H -> C. Reduced but not abolished antiviral activity.
Mutagenesis	249 – 249	H -> R. Nearly abolished antiviral activity; when associated with R-65.
Mutagenesis	251 – 251	E -> A. Decrease in cytidine deaminase and antiviral activity.
Mutagenesis	251 – 251	E -> A. Decrease in cytidine deaminase and antiviral activity; when associated with A-67.
Mutagenesis	251 – 251	E -> Q. Remains able to bind Vif.
Mutagenesis	251 – 251	Missing. Reduced but not abolished antiviral activity. Nearly abolished antiviral activity; when associated with Q-67.

Literature citations

Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS THR-178; ILE-231 AND CYS-307;