Variant position: 53 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 279 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RETDYSDGDPLDVHKRLPSS AGEDRAVMLGFAMMGFSVLMF
Rat ----ISNGDPLKVHPKLPSS AGEDRATLLGIAMMASSVLMF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 279 Calcium-activated potassium channel subunit beta-3
1 – 60 Cytoplasmic
Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2.
Riazi M.A.; Brinkman-Mills P.; Johnson A.; Naylor S.L.; Minoshima S.; Shimizu N.; Baldini A.; McDermid H.E.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3); VARIANT THR-53; TISSUE SPECIFICITY;
Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.
Brenner R.; Jegla T.J.; Wickenden A.; Liu Y.; Aldrich R.W.;
J. Biol. Chem. 275:6453-6461(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4); VARIANT THR-53; TISSUE SPECIFICITY; INTERACTION WITH KCNMA1;
Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel.
Uebele V.N.; Lagrutta A.A.; Wade T.; Figueroa D.J.; Liu Y.; McKenna E.; Austin C.P.; Bennett P.B.; Swanson R.;
J. Biol. Chem. 275:23211-23218(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4); FUNCTION; ALTERNATIVE SPLICING; TISSUE SPECIFICITY; VARIANTS THR-53 AND SER-165;
A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.
Meera P.; Wallner M.; Toro L.;
Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT THR-53; GLYCOSYLATION;
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.
Behrens R.; Nolting A.; Reimann F.; Schwarz M.; Waldschuetz R.; Pongs O.;
FEBS Lett. 474:99-106(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4); VARIANT THR-53;
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