Variant position: 98 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 434 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PFRKGACEITRKTRRQCQAC RLRKCLESGMKKEMIMSDEAV
Rhesus macaque PFRKGACEITRKTRRQCQAC RLRKCLESGMKKEMIMSDAAV
Mouse PFRKGTCEITRKTRRQCQAC RLRKCLESGMKKEMIMSDAAV
Rat PFRKGTCEITRKTRRQCQAC RLRKCLESGMKKEMIMSDAAV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 434 Nuclear receptor subfamily 1 group I member 2
38 – 107 Nuclear receptor
77 – 102 NR C4-type
Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations.
Koyano S.; Kurose K.; Ozawa S.; Saeki M.; Nakajima Y.; Hasegawa R.; Komamura K.; Ueno K.; Kamakura S.; Nakajima T.; Saito H.; Kimura H.; Goto Y.; Saitoh O.; Katoh M.; Ohnuma T.; Kawai M.; Sugai K.; Ohtsuki T.; Suzuki C.; Minami N.; Saito Y.; Sawada J.;
Drug Metab. Pharmacokinet. 17:561-565(2002)
Cited for: VARIANTS CYS-98; GLN-148; TRP-381 AND VAL-403;
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