Sequence information
Variant position: 340 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 511 The length of the canonical sequence.
Location on the sequence:
TTSGISWFLYCMALYPEHQH
R CREEVREILGDQDFFQWDDL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TTSGISWFLYCMALYPEHQHR CREEVREILGDQDFFQWDDL
Mouse TTSGISWFLYCMALYPMHQQR CREEVREILGDRDSFQWDDL
Rat TTSGISWFLYCMALYPEHQQL CREEVRGILGDQDSFQWDDL
Rabbit TTSGISWFLYCMALYPEHQQR CREEVREILGDQDSFQWEDL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 511
Cytochrome P450 4B1
Literature citations
Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant.
Lo-Guidice J.-M.; Allorge D.; Cauffiez C.; Chevalier D.; Lafitte J.-J.; Lhermitte M.; Broly F.;
Pharmacogenetics 12:367-374(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS TRP-173; GLY-322; ILE-331; CYS-340 AND CYS-375;
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-111; TRP-173; TRP-264; GLN-274; GLY-322; SER-329; ILE-331; CYS-340; CYS-354; CYS-375 AND GLN-482;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.