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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P35916: Variant p.Pro954Ser

Vascular endothelial growth factor receptor 3
Gene: FLT4
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Variant information Variant position: help 954 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Proline (P) to Serine (S) at position 954 (P954S, p.Pro954Ser). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and polar (S) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In HCI. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 954 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 1363 The length of the canonical sequence.
Location on the sequence: help NLSNFLRAKRDAFSPCAEKS P EQRGRFRAMVELARLDRRRP The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         NLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRP

Mouse                         NLSNFLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRP

Rat                           NLSNFLRVKRETFDPYAEKSPEQRRRFRAMVEGAKADRRRL

Zebrafish                     NLSNFLRAKREFFLPYRDRSPKTQSQVRRMIEAGQASQSEH
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 25 – 1363 Vascular endothelial growth factor receptor 3
Topological domain 797 – 1363 Cytoplasmic
Domain 845 – 1173 Protein kinase
Alternative sequence 766 – 1298 Missing. In isoform 3.



Literature citations
Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.
Walter J.W.; North P.E.; Waner M.; Mizeracki A.; Blei F.; Walker J.W.T.; Reinisch J.F.; Marchuk D.A.;
Genes Chromosomes Cancer 33:295-303(2002)
Cited for: VARIANTS HCI SER-954 AND SER-1137; VARIANTS ALA-494; GLN-890 AND HIS-1146;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.