Variant position: 651 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 749 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EKDCPTIIHFVLANINFRKY RAPGVPRETEEEKEIADFDIF
Mouse EKDCPTIIHFVLANINFRKY KAPGVLRETKEEKEIADFDIF
Rat EKDCPTIIHFVLANINFRKY KAPGVLRETKEEKEIADFDIF
Bovine EKDCPTIIHFVLANINFRKY KAPGVPRETNEEKEIADFDIF
Rabbit EKDCPIIIHFVLANINFRKY KSPGVPRETKEEKEIADFDIF
Horse EKDCPTIIHFVLANINFRKY KAPGVPRETKEEKEIADFDIF
Chicken EKDCPTIIHFVLANINFRKY KAPGLPRESKEEKDFADFDIF
Xenopus laevis EKDCPTVIHFVLANLQFRNF KAPGVPRETTEEKESADFDIF
Xenopus tropicalis EKDCPTVIHFVLANLQFRNF KAPGVPRETAEEKEFADFDIF
Zebrafish -KNCPTIIHFVLANINFRNF KAPGVPRDSDKDIEFGDFDIF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 749 Cytosolic phospholipase A2
140 – 740 PLA2c
634 – 634 C -> A. No effect on phospholipase activity; when associated with A-620.
650 – 652
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP.
Clark J.D.; Lin L.-L.; Kriz R.W.; Ramesha C.S.; Sultzman L.A.; Lin A.Y.; Milona N.; Knopf J.L.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PARTIAL PROTEIN SEQUENCE; VARIANT LYS-651;
Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2.
Sharp J.; White D.; Chiou G.; Goodson T.; Gamboa G.; McClure D.; Burgett S.; Hoskins J.; Skatrud P.; Sportsman J.; Becker G.; Kang L.; Roberts E.; Kramer R.;
J. Biol. Chem. 266:14850-14853(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT LYS-651;
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ILE-224 AND LYS-651;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT LYS-651;
Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.
Adler D.H.; Cogan J.D.; Phillips J.A.; Schnetz-Boutaud N.; Milne G.L.; Iverson T.; Stein J.A.; Brenner D.A.; Morrow J.D.; Boutaud O.; Oates J.A.;
J. Clin. Invest. 118:2121-2131(2008)
Cited for: INVOLVEMENT IN GURDP; VARIANTS GURDP PRO-111 AND HIS-485; VARIANT LYS-651; FUNCTION; CATALYTIC ACTIVITY; PATHWAY;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.