Variant position: 409 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 540 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PAAPTPAGATGGSSAWLDSS SENRGLGSELSKPGVLASQVD
Mouse PEGPATKVTTGGNQTGPNSS IRSLHSGPEMSKPGVLVSQLD
Rat LEAPATVVTTGSSLTRPDIS SRSLHSGPELSKPGVLVSQVD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 540 Mitochondrial antiviral-signaling protein
1 – 513 Cytoplasmic
373 – 419 Disordered
400 – 415 Polar residues
408 – 408 Phosphoserine
125 – 540 Missing. In isoform 5.
132 – 540 Missing. In isoform 2 and isoform 6.
149 – 540 Missing. In isoform 3.
427 – 427 Q -> A. No cleavage by HHAV 3ABC.
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
Seth R.B.; Sun L.; Ea C.-K.; Chen Z.J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; TISSUE SPECIFICITY; MUTAGENESIS OF THR-54 AND 67-GLY--VAL-69; INTERACTION WITH DDX58/RIG-I AND TRAF6; SUBCELLULAR LOCATION; VARIANTS LYS-198 AND PHE-409;
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Meylan E.; Curran J.; Hofmann K.; Moradpour D.; Binder M.; Bartenschlager R.; Tschopp J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH DDX58/RIG-I; IKBKE; CHUK AND IKBKB; FUNCTION; MUTAGENESIS OF CYS-508; VARIANTS LYS-198 AND PHE-409; INTERACTION WITH HCV NS3/4A PROTEASE (MICROBIAL INFECTION); PROTEOLYTIC CLEAVAGE (MICROBIAL INFECTION);
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS GLU-93; LYS-198 AND PHE-409;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.