Variant position: 423 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 524 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AIFLFVSFFEIGPGPIPWFM- VAEFFSQGPRPAALAIAAFSN
Mouse AIFLFVSFFEIGPGPIPWFM- VAEFFSQGPRPTALALAAFS
Rat AIFLFVSFFEIGPGPIPWFM- VAEFFSQGPRPTALALAAFS
Pig AIFLFVSFFEIGPGPIPWFM- VAEFFSQGPRPAALAMAAFS
Bovine AIFLFVSFFEIGPGPIPWFM- VAEFFSQGPRPAALAIAAFS
Chicken AIFLFVIFFEVGPGPIPWFI- VAELFSQGPRPAAIAVAGFC
Baker's yeast SNPVDIQMYEVCSEFIDVTID LFDLYKAPVLRNSQ-KSSDK
Fission yeast SSPVDVQSYEICSDFIDVILD IGSIYG----RSSQLKPGHS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 524 Solute carrier family 2, facilitated glucose transporter member 2
422 – 433 Cytoplasmic
412 – 412 D-glucose
420 – 420 D-glucose
Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome.
Sakamoto O.; Ogawa E.; Ohura T.; Igarashi Y.; Matsubara Y.; Narisawa K.; Iinuma K.;
Pediatr. Res. 48:586-589(2000)
Cited for: VARIANTS FBS PRO-389 AND GLU-423;
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