Sequence information
Variant position: 227 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 277 The length of the canonical sequence.
Location on the sequence:
AILLVLVFIKKVAKKPTNKA
P HPKQEPQEINFPDDLPGSNT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AILLVLVFIKKVAKKP-TNKAP HPK---QEPQEINFPDDLP-GSNT
VVLLVSACIRKVVKKP-ENKVM Y-----QDPVE--DLEEFP
Mouse TIFGVFLYIKKVVKKPKDNEIL PPAARRQDPQE---MEDYP
Pig AVLLVFLCIRKVTKEQ-ETKAL HPKTERQDPVETIDLEDFP
Bovine AVLLVSACIRNITKKR-QAKAL HPTAERQDPVETIDPEDFP
Horse AVLLLSACIRKVAKEP-ENKAL HRKVGWQDPVETVYPDDFP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
21 – 277
Tumor necrosis factor receptor superfamily member 5
Topological domain
216 – 277
Cytoplasmic
Alternative sequence
204 – 277
Missing. In isoform II.
Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LEU-124 AND ALA-227;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.