Variant position: 224 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 749 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GFSGVMKALYESGILDCATY VAGLSGSTWYMSTLYSHPDFP
Mouse GFSGVMKALYESGILDCATY IAGLSGSTWYMSTLYSHPDFP
Rat GFSGVMKALYESGILDCATY VAGLSGSTWYMSTLYSHPDFP
Bovine GFSGVMKALYESGILDCATY IAGLSGSTWYMSTLYSHPDFP
Rabbit GFSGVMKALYESGILDCATY IAGLSGSTWYMSTLYSHPDFP
Horse GFSGVMKALYESGILDCATY LAGLSGSSWYMSTLYSHPDFP
Chicken GFAGVMKALYESGVLDCATY IAGLSGSTWYMSTLYSHPDFP
Xenopus laevis GFSGVMKALYESGVLDCATY VAGLSGSTWYMSTLYSHPDFP
Xenopus tropicalis GFSGVMKALFESGVLDCVTY IAGLSGSTWYMSALYSHADFP
Zebrafish GFSGVMKALYESGVFDCATY VAGLSGSTWYMSMLYSHPEFP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 749 Cytosolic phospholipase A2
140 – 740 PLA2c
228 – 228 Nucleophile
215 – 215 S -> A. No effect on phospholipase or lysophospholipase activity.
220 – 220 C -> A. No effect on phospholipase activity.
228 – 228 S -> ACT. Abolishes both phospholipase and lysophospholipase activities.
221 – 226
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ILE-224 AND LYS-651;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.