Sequence information
Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 173 The length of the canonical sequence.
Location on the sequence:
FTEKHEWVTTENGIGTVGIS
N FAQEALGDVVYCSLPEVGTK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FTEKHEWVTTENGIGT-VGISN FAQEALGDVVYCSLPEVGTK
Mouse FTEKHEWITTEEGIGT-VGISN FAQEALGDVVYCSLPEVGT
Rat FTEKHEWVTAKDGIGT-VGISN FAQEALGDVVYCSLPEVGT
Bovine FTEKHEWVTTENGVGT-VGISN FAQEALGDVVYCSLPEVGT
Rabbit FTEKHEWITTENGIGT-VGISN FAQEALGDVVYCSLPEVGT
Chicken FTDKHEWISVENGIGT-VGISN FAQEALGDVVYCSLPEIGT
Drosophila YTNKHEWVEVVSGSNAIVGISS YAQEALGDVVFAQLPEPGT
Baker's yeast YTSQHEWIAVHQDKTAFVGITK YATDALGDATYVELPEVGT
Fission yeast FTKEHEWVKVDGDVGT-VGITS YAANALGEVVFVELPEPET
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
49 – 173
Glycine cleavage system H protein, mitochondrial
Domain
66 – 148
Lipoyl-binding
Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LEU-21 AND SER-73;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.