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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O15197: Variant p.Arg499Gln

Ephrin type-B receptor 6
Gene: EPHB6
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Variant information Variant position: help 499
Type of variant: help LB/B
Residue change: help From Arginine (R) to Glutamine (Q) at position 499 (R499Q, p.Arg499Gln).
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (Q)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 499
Protein sequence length: help 1021
Location on the sequence: help INVSTSHEVPSAVPVVHQVS R ASNSITVSWPQPDQTNGNIL
Residue conservation: help 
Human                         INVSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNIL

Chimpanzee                    INVSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNIL

Mouse                         INVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNGNIL

Rat                           INVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNGNIL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 32 – 1021 Ephrin type-B receptor 6
Topological domain 32 – 594 Extracellular
Domain 487 – 582 Fibronectin type-III 2
Glycosylation 480 – 480 N-linked (GlcNAc...) asparagine
Alternative sequence 487 – 540 VPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTS -> GELFSLAFRIPCLRSFEPPSLLLISSLVHPCRPPLKADPAPRDSYPHNNFPFAL. In isoform 3.



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-122; ARG-282; ALA-324 AND GLN-499;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.