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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P23219: Variant p.Arg53His

Prostaglandin G/H synthase 1
Gene: PTGS1
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Variant information Variant position: help 53
Type of variant: help LB/B
Residue change: help From Arginine (R) to Histidine (H) at position 53 (R53H, p.Arg53His).
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (H)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 53
Protein sequence length: help 599
Location on the sequence: help NPCCYYPCQHQGICVRFGLD R YQCDCTRTGYSGPNCTIPGL
Residue conservation: help
Human                         NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGL

                              NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEL

Mouse                         NPCCYYPCQNQGVCVRFGLDNYQCDCTRTGYSGPNCTIPEI

Rat                           NPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEI

Bovine                        NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYYGPNCTIPEI

Rabbit                        NPCCYFPCQHQGVCVRVALDRYQCDCTRTGYSGPNCTVPDL

Sheep                         NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEI

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 24 – 599 Prostaglandin G/H synthase 1
Domain 31 – 69 EGF-like
Glycosylation 67 – 67 N-linked (GlcNAc...) asparagine
Disulfide bond 36 – 158
Disulfide bond 40 – 56
Alternative sequence 1 – 109 Missing. In isoform 4.
Beta strand 53 – 57



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS ARG-8; LEU-17; HIS-53; LEU-149 AND MET-237;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.