UniProtKB/SwissProt variant VAR

Prostaglandin G/H synthase 1
Gene: PTGS1
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Variant information Variant position:

53
Type of variant:

LB/B
Residue change:

From Arginine (R) to Histidine (H) at position 53 (R53H, p.Arg53His).
Physico-chemical properties:

Change from large size and basic (R) to medium size and polar (H)
BLOSUM score:

0
Other resources:

Variant rs3842789 [ dbSNP | Ensembl ]

Sequence information Variant position:

53
Protein sequence length:

599
Location on the sequence:

NPCCYYPCQHQGICVRFGLD R YQCDCTRTGYSGPNCTIPGL
Residue conservation:

Human                         NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGL

                              NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEL

Mouse                         NPCCYYPCQNQGVCVRFGLDNYQCDCTRTGYSGPNCTIPEI

Rat                           NPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEI

Bovine                        NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYYGPNCTIPEI

Rabbit                        NPCCYFPCQHQGVCVRVALDRYQCDCTRTGYSGPNCTVPDL

Sheep                         NPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEI

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	24 – 599	Prostaglandin G/H synthase 1
Domain	31 – 69	EGF-like
Glycosylation	67 – 67	N-linked (GlcNAc...) asparagine
Disulfide bond	36 – 158
Disulfide bond	40 – 56
Alternative sequence	1 – 109	Missing. In isoform 4.
Beta strand	53 – 57

Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS ARG-8; LEU-17; HIS-53; LEU-149 AND MET-237;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P23219: Variant p.Arg53His