Variant position: 70 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 418 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EYISSRMAGGGQKVCYIEGH RVINLANEMFGYNGWAHSITQ
Mouse EYISSRMAGGGQKVCYIEGH RVINLANEMFGYNGWAHSITQ
Chicken EYISSRQAGGGQKVCYIEGH KVISLANEMFGFNGWAHSVTQ
Baker's yeast EYISKRVGFGTSRIAYIEGW RVINLANQIFGYNGWSTEVKS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 418 DNA repair protein RAD52 homolog
55 – 55 R -> A. Abolishes ssDNA-binding.
65 – 65 Y -> A. Moderately defective in both ss and dsDNA-binding.
68 – 79
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS TRP-70; GLU-221 AND ASN-287;
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