Sequence information
Variant position: 50 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 933 The length of the canonical sequence.
Location on the sequence:
RPAAGPFPGSQTSDTLPEVS
A IPISLDGLLFPRPCQGQDPS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RPAAGPFPGSQTSDTLPEVSA IPISL-----------DGLLFPRPCQGQDPS
Gorilla RPAAGPYPGSQTSDTLPEVSA IPISL-----------DGLL
RRDGGRLRASQTSDAPRVAAA AAAAAAAASAAPSAPSDRLL
Chimpanzee RPAAGPFPGSQTSDTLPEVSA IPISL-----------DGLL
Mouse RLDSGPFQGSQHSDVSSVVSP IPISL-----------DGLL
Rat RLDPDPFQGSQHSDASSVVSP IPISL-----------DRLL
Rabbit RPDPGPFQGSQTSEASSVVSA IPISL-----------DGLL
Chicken AP---PSRG--------EAEG IDVAL-----------DGLL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 933
Progesterone receptor
Region
1 – 566
Modulating, Pro-Rich
Region
1 – 164
AF3; mediates transcriptional activation (in isoform B)
Region
1 – 157
Disordered
Alternative sequence
1 – 594
Missing. In isoform 3.
Alternative sequence
1 – 164
Missing. In isoform A.
Alternative sequence
17 – 635
Missing. In isoform 4.
Mutagenesis
55 – 55
L -> A. Reduces transcriptional activation; when associated with A-58 and A-59.
Mutagenesis
58 – 58
L -> A. Reduces transcriptional activation; when associated with A-55 and A-59.
Mutagenesis
59 – 59
L -> A. Reduces transcriptional activation; when associated with A-55 and A-58.
Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-50; VAL-120; LEU-186; ARG-301; THR-344; SER-444; LEU-529; PRO-536; VAL-651 AND LEU-865;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.