Variant position: 186 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 933 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SRSGCKVGDSSGTAAAHKVL PRGLSPARQLLLPASESPHWS
Gorilla SRSGGKAGDSSGTAAAHKVL PRGLSPSRQLLLPVSGSPHWS
Chimpanzee SRSGCKAGDSSGTAAAHKVL PRGLSPSRQLLLPASGSPHWS
Mouse SRPEIKAGDSSGTGAGQKVL PKGLSPPRQLLLPTSGSAHWP
Rat SRPESKAGDSSGTGAGQKVL PKAVSPPRQLLLPTSGSAHWP
Rabbit SRPEDKAGDSSGTAAAHKVL PRGLSPSRQLLLPSSGSPHWP
Chicken RGPEQKAVDAG--------- PGAPGPSQ----PRPGAPLWP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 933 Progesterone receptor
1 – 566 Modulating, Pro-Rich
165 – 305 Mediates transcriptional transrepression (in isoform A)
183 – 187 Nuclear localization signal
190 – 190 Phosphoserine
1 – 594 Missing. In isoform 3.
17 – 635 Missing. In isoform 4.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-50; VAL-120; LEU-186; ARG-301; THR-344; SER-444; LEU-529; PRO-536; VAL-651 AND LEU-865;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.