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UniProtKB/Swiss-Prot P06401: Variant p.Leu651Val

Progesterone receptor
Gene: PGR
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Variant information Variant position: help 651
Type of variant: help LB/B
Residue change: help From Leucine (L) to Valine (V) at position 651 (L651V, p.Leu651Val).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 651
Protein sequence length: help 933
Location on the sequence: help GMVLGGRKFKKFNKVRVVRA L DAVALPQPVGVPNESQALSQ
Residue conservation: help 
Human                         GMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQ

Gorilla                       GMVLGGRKFKKFNKVRVVRALDAVALPQPVGIPNESQALSQ

                              GMVLGGRKFKKFNKVRVMRTLDAVALPQPVGIPNESQALSQ

Chimpanzee                    GMVLGGRKFKKFNKVRVVRALDAVALPQPVGIPNESQALSQ

Mouse                         GMVLGGRKFKKFNKVRVMRTLDGVALPQSVGLPNESQALGQ

Rat                           GMVLGGRKFKKFNKVRVMRALDGVALPQSVAFPNESQTLGQ

Rabbit                        GMVLGGRKFKKFNKVRVMRALDAVALPQPVGIPNES----Q

Chicken                       GMVLGGRKFKKLNKMKVVRTLD-VALQQPAVLQDETQSLTQ
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 933 Progesterone receptor
Alternative sequence 636 – 737 Missing. In isoform 5.



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-50; VAL-120; LEU-186; ARG-301; THR-344; SER-444; LEU-529; PRO-536; VAL-651 AND LEU-865;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.