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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P24530: Variant p.Pro5Thr

Endothelin receptor type B
Gene: EDNRB
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Variant information Variant position: help 5
Type of variant: help LB/B
Residue change: help From Proline (P) to Threonine (T) at position 5 (P5T, p.Pro5Thr).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to medium size and polar (T)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 5
Protein sequence length: help 442
Location on the sequence: help MQPP P SLCGRALVALVLACGLSRIW
Residue conservation: help 
Human                         MQPPPSLCGRALVALVLACGLSRIW

                              MQPPPSLCGRALVALVLACGLSRIW

Mouse                         MQSPASRCGRALVALLLACGFLGVW

Rat                           MQSSASRCGRALVALLLACGLLGVW

Pig                           MQPLRSLCGRALVALIFACGVAGVQ

Bovine                        MQPLPSLCGRALVALILACGVAGIQ

Rabbit                        MQPPPSLCGLALLALVLACGMAEVW

Horse                         MQPLPTLCGRVLVALILACGVAGVQ
Sequence annotation in neighborhood: help
TypePositionsDescription
Signal peptide 1 – 26
Alternative sequence 1 – 1 M -> MNKSTCLMAAETPSKRWRLHCLAFSQRFVRAGPACSSREACSSPRAGWNPAGFRLPGRWSPFVALHLVCQIREALKLRSGHRTPSGAGSSM. In isoform C.



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-5 AND ASN-305;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.