Sequence information
Variant position: 57 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 375 The length of the canonical sequence.
Location on the sequence:
VRIKMVAVGICHTDDHVVSG
N LVTPLPVILGHEAAGIVESV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VRIKMVAVGICHTDDHVVSGN LVTPLPVILGHEAAGIVESV
Chimpanzee VRIKMVAVGICRTDDHVVSGN LVTPLPAILGHEAAGIVESV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 375
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
Metal binding
47 – 47
Zinc 1; catalytic
Metal binding
68 – 68
Zinc 1; catalytic
Beta strand
56 – 58
Literature citations
Nucleotide sequence of the ADH2(3) gene encoding the human alcohol dehydrogenase beta 3 subunit.
Carr L.G.; Xu Y.; Ho W.H.; Edenberg H.J.;
Alcohol. Clin. Exp. Res. 13:594-596(1989)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LYS-57 AND CYS-370; POLYMORPHISM;
Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification.
Xu Y.L.; Carr L.G.; Bosron W.F.; Li T.K.; Edenberg H.J.;
Genomics 2:209-214(1988)
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA]; VARIANT LYS-57;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.