Variant position: 422 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1630 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DDARTGEKVLTCYLLPQQPP PSLEDAGQQGSLSETW-SDAPP
Mouse DDAQTGEKVLTCYLLPQQPL PSLEDAGQQSSPSESC-SDAP
Zebrafish DDEQTGEKVLTCYLLPQQPS SSLENL-LERSVDEAWPTDTN
Drosophila TDAETGEQVLSCYLLPQQEY QPITPARDLESDSEPF-EERE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1630 Protein scribble homolog
1 – 818 Sufficient for targeting to adherens junction and to inhibit cell proliferation
417 – 440 Disordered
The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.
Petit M.M.R.; Meulemans S.M.P.; Alen P.; Ayoubi T.A.Y.; Jansen E.; Van de Ven W.J.M.;
BMC Cell Biol. 6:1-1(2005)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH LPP; SUBCELLULAR LOCATION; MUTAGENESIS OF 738-LEU--GLY-739; 872-LEU--GLY-873; 1014-LEU--GLY-1015 AND 1111-LEU--GLY-1112; VARIANT LEU-422;
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.
Navarro C.; Nola S.; Audebert S.; Santoni M.-J.; Arsanto J.-P.; Ginestier C.; Marchetto S.; Jacquemier J.; Isnardon D.; Le Bivic A.; Birnbaum D.; Borg J.-P.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT LEU-422; SUBCELLULAR LOCATION; MUTAGENESIS OF PRO-305; TISSUE SPECIFICITY;
The human Scrib N1 variant encoded by the SCRIB gene contains 13 leucine-rich repeats and 4 PDZ domains.
Petit M.M.R.; Alen P.; Meulemans S.M.P.; Van de Wouwer E.; Ayoubi T.A.Y.; Van de Ven W.J.M.; Jansen E.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANT LEU-422;
Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
Nagase T.; Seki N.; Tanaka A.; Ishikawa K.; Nomura N.;
DNA Res. 2:167-174(1995)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT LEU-422;
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