Sequence information
Variant position: 422 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1630 The length of the canonical sequence.
Location on the sequence:
DDARTGEKVLTCYLLPQQPP
P SLEDAGQQGSLSETWSDAPP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DDARTGEKVLTCYLLPQQPPP SLEDAGQQGSLSETW-SDAPP
Mouse DDAQTGEKVLTCYLLPQQPLP SLEDAGQQSSPSESC-SDAP
Zebrafish DDEQTGEKVLTCYLLPQQPSS SLENL-LERSVDEAWPTDTN
Drosophila TDAETGEQVLSCYLLPQQEYQ PITPARDLESDSEPF-EERE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1630
Protein scribble homolog
Region
1 – 818
Sufficient for targeting to adherens junction and to inhibit cell proliferation
Region
417 – 440
Disordered
Literature citations
The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.
Petit M.M.R.; Meulemans S.M.P.; Alen P.; Ayoubi T.A.Y.; Jansen E.; Van de Ven W.J.M.;
BMC Cell Biol. 6:1-1(2005)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH LPP; SUBCELLULAR LOCATION; MUTAGENESIS OF 738-LEU--GLY-739; 872-LEU--GLY-873; 1014-LEU--GLY-1015 AND 1111-LEU--GLY-1112; VARIANT LEU-422;
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.
Navarro C.; Nola S.; Audebert S.; Santoni M.-J.; Arsanto J.-P.; Ginestier C.; Marchetto S.; Jacquemier J.; Isnardon D.; Le Bivic A.; Birnbaum D.; Borg J.-P.;
Oncogene 24:4330-4339(2005)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT LEU-422; SUBCELLULAR LOCATION; MUTAGENESIS OF PRO-305; TISSUE SPECIFICITY;
The human Scrib N1 variant encoded by the SCRIB gene contains 13 leucine-rich repeats and 4 PDZ domains.
Petit M.M.R.; Alen P.; Meulemans S.M.P.; Van de Wouwer E.; Ayoubi T.A.Y.; Van de Ven W.J.M.; Jansen E.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANT LEU-422;
Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
Nagase T.; Seki N.; Tanaka A.; Ishikawa K.; Nomura N.;
DNA Res. 2:167-174(1995)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT LEU-422;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.