UniProtKB/SwissProt variant VAR

Stabilin-2
Gene: STAB2
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Variant information Variant position:

510
Type of variant:

LB/B
Residue change:

From Proline (P) to Histidine (H) at position 510 (P510H, p.Pro510His).
Physico-chemical properties:

Change from medium size and hydrophobic (P) to medium size and polar (H)
BLOSUM score:

-2
Other resources:

Variant rs1609860 [ dbSNP | Ensembl ]

Sequence information Variant position:

510
Protein sequence length:

2551
Location on the sequence:

DIIASNGLLHILDRAMDKLE P TFESNNEQTIMTMLQPRYSK
Residue conservation:

Human                         DIIASNGLLHILDRAMDKLEPTFESNNEQTIMTMLQPRYSK

Mouse                         NIVASNGLVHILDRAMDKIEPTLESNPQQTIMTMLQPRYGK

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	20 – 2551	Stabilin-2
Topological domain	20 – 2458	Extracellular

Literature citations
Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.
Politz O.; Gratchev A.; McCourt P.A.G.; Schledzewski K.; Guillot P.; Johansson S.; Svineng G.; Franke P.; Kannicht C.; Kzhyshkowska J.; Longati P.; Velten F.W.; Johansson S.; Goerdt S.;
Biochem. J. 362:155-164(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; TISSUE SPECIFICITY; VARIANT HIS-510; FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities.
Adachi H.; Tsujimoto M.;
J. Biol. Chem. 277:34264-34270(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; TISSUE SPECIFICITY; VARIANT HIS-510;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q8WWQ8: Variant p.Pro510His