Variant position: 137 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 344 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VERDTNVDEPVEWETPDLSQ AEIEQKIKEYNAQINSNLFMS
Mouse LERDTNVDEAVERETPDLSQ AETEQKIKDYNGQINSNLFMS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 344 Ras association domain-containing protein 1
1 – 155 Missing. In isoform B.
84 – 149 RLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTNVDEPVEWETPDLSQAEIEQKIKEYNAQ -> QQGRFLHRLHQGSAEAGAPCLCALQQEATLLAGCPAGPRTGHKCQAPHFLLPAQGCCQAPACAVTHKGT. In isoform G.
93 – 344 Missing. In isoform F.
123 – 123 V -> VPILQ. In isoform E.
Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.
Burbee D.G.; Forgacs E.; Zochbauer-Muller S.; Shivakumar L.; Fong K.; Gao B.; Randle D.; Kondo M.; Virmani A.; Bader S.; Sekido Y.; Latif F.; Milchgrub S.; Toyooka S.; Gazdar A.F.; Lerman M.I.; Zabarovsky E.; White M.; Minna J.D.;
J. Natl. Cancer Inst. 93:691-699(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; C; D; E; F AND G); FUNCTION; TISSUE SPECIFICITY; VARIANTS GLN-21; CYS-53; GLU-133; SER-137 AND CYS-329;
The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.
Shivakumar L.; Minna J.; Sakamaki T.; Pestell R.; White M.A.;
Mol. Cell. Biol. 22:4309-4318(2002)
Cited for: FUNCTION; VARIANT PHE-135; CHARACTERIZATION OF VARIANTS PHE-135 AND SER-137;
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