Sequence information
Variant position: 325 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 747 The length of the canonical sequence.
Location on the sequence:
ENQTYQALDSLNTSRRVLIS
G TPIQNDLLEYFSLVHFVNSG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ENQTYQALDSLNTSRRVLISG TPIQNDLLEYFSLVHFVNSG
Mouse ENQTYQALDSLNTSRRVLISG TPIQNDLLEYFSLVHFVNSG
Zebrafish DNQTYLALNSMNAQRRVLISG TPIQNDLLEYFSLVHFVNSG
Drosophila DNLTYQALMGLKTKRRVLLSG TPIQNDLTEYYSLVNFVNPE
Baker's yeast DSLTFTALDSISCPRRVILSG TPIQNDLSEYFALLSFSNPG
Fission yeast DSLTFTALDKLNVQRRVILSG TPIQNDLSEYFSLLNFANPG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 747
DNA repair and recombination protein RAD54-like
Domain
170 – 345
Helicase ATP-binding
Literature citations
Mutations in the RAD54 recombination gene in primary cancers.
Matsuda M.; Miyagawa K.; Takahashi M.; Fukuda T.; Kataoka T.; Asahara T.; Inui H.; Watatani M.; Yasutomi M.; Kamada N.; Dohi K.; Kamiya K.;
Oncogene 18:3427-3430(1999)
Cited for: VARIANTS HIS-63; GLU-151; ARG-325 AND GLU-444;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.