Variant position: 511 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 718 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FLFSREEADTLRLKVEELEG ERSRLEEEKRMLEAQLERRAL
Mouse FSFCKEEVDALRLKVEELEG ERSRLEQEKQVLEMQMEKLTL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 718 Mitotic spindle assembly checkpoint protein MAD1
380 – 532 Necessary for interaction with NEK2
46 – 632
494 – 528
Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers.
Nomoto S.; Haruki N.; Takahashi T.; Masuda A.; Koshikawa T.; Takahashi T.; Fujii Y.; Osada H.; Takahashi T.;
Cited for: VARIANT LUNG CANCER ALA-299; VARIANTS SER-160; MET-500; LYS-511; HIS-556 AND HIS-558;
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