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UniProtKB/Swiss-Prot O95185: Variant p.Met721Thr

Netrin receptor UNC5C
Gene: UNC5C
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Variant information Variant position: help 721
Type of variant: help LB/B
Residue change: help From Methionine (M) to Threonine (T) at position 721 (M721T, p.Met721Thr).
Physico-chemical properties: help Change from medium size and hydrophobic (M) to medium size and polar (T)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 721
Protein sequence length: help 931
Location on the sequence: help VYCLDDTQDALKEILHLERQ M GGQLLEEPKALHFKGSTHNL
Residue conservation: help 
Human                         VYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNL

Mouse                         VYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNL

Rat                           VYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNL

Chicken                       VYCLDDTQDALKEVLQLERQMGGQLLEEPKTLHFKGSTHNL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 41 – 931 Netrin receptor UNC5C
Topological domain 402 – 931 Cytoplasmic
Region 402 – 931 Required for netrin-mediated axon repulsion of neuronal growth cones
Alternative sequence 579 – 931 Missing. In isoform 2.



Literature citations
Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.
Ackerman S.L.; Knowles B.B.;
Genomics 52:205-208(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANT THR-721;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.