Variant position: 721 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 931 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VYCLDDTQDALKEILHLERQ MGGQLLEEPKALHFKGSTHNL
Mouse VYCLDDTQDALKEVLQLERQ MGGQLLEEPKALHFKGSIHNL
Rat VYCLDDTQDALKEVLQLERQ MGGQLLEEPKALHFKGSIHNL
Chicken VYCLDDTQDALKEVLQLERQ MGGQLLEEPKTLHFKGSTHNL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
41 – 931 Netrin receptor UNC5C
402 – 931 Cytoplasmic
402 – 931 Required for netrin-mediated axon repulsion of neuronal growth cones
579 – 931 Missing. In isoform 2.
Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.
Ackerman S.L.; Knowles B.B.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANT THR-721;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.