Variant position: 351 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 465 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LCPRPGCGAGLLPEPDQRKV TCEGGNGLGCGFAFCRECKEA
Mouse LCPRPGCGAGLLPEQGQRKV TCEGGNGLGCGFVFCRDCKEA
Rat LCPRPGCGAGLLPEQGQKKV TCEGGNGLGCGFVFCRDCKEA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease.
Beasley S.A.; Hristova V.A.; Shaw G.S.;
Proc. Natl. Acad. Sci. U.S.A. 104:3095-3100(2007)
Cited for: STRUCTURE BY NMR OF 307-384 IN COMPLEX WITH ZINC IONS; CHARACTERIZATION OF VARIANT PARK2 PRO-351; MUTAGENESIS OF CYS-332 AND CYS-365; IDENTIFICATION BY MASS SPECTROMETRY;
Role of parkin mutations in 111 community-based patients with early-onset parkinsonism.
Kann M.; Jacobs H.; Mohrmann K.; Schumacher K.; Hedrich K.; Garrels J.; Wiegers K.; Schwinger E.; Pramstaller P.P.; Breakefield X.O.; Ozelius L.J.; Vieregge P.; Klein C.;
Ann. Neurol. 51:621-625(2002)
Cited for: VARIANTS PARK2 LEU-37 AND PRO-351;
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