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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q15788: Variant p.Ser999Phe

Nuclear receptor coactivator 1
Gene: NCOA1
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Variant information Variant position: help 999 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Phenylalanine (F) at position 999 (S999F, p.Ser999Phe). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to large size and aromatic (F) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 999 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 1441 The length of the canonical sequence.
Location on the sequence: help TPPLIMEERPNLYSQPYSSP S PTANLPSPFQGMVRQKPSLG The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         TPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLG

Mouse                         TPPLMMEDRPTLYSQPYSSPSPTAGLSGPFQGMVRQKPSLG

Pig                           TPPLMMEERPNLYSQPYSSPSPTANLSGPFQGMVRQKPSLG

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 1441 Nuclear receptor coactivator 1



Literature citations
Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.
Takeshita A.; Yen P.M.; Misiti S.; Cardona G.R.; Liu Y.; Chin W.W.;
Endocrinology 137:3594-3597(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3); INTERACTION WITH GTF2B; VARIANTS LYS-457; LYS-466; PRO-474; THR-591; ALA-685; PHE-999 AND THR-1154; The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.
Onate S.A.; Boonyaratanakornkit V.; Spencer T.E.; Tsai S.Y.; Tsai M.-J.; Edwards D.P.; O'Malley B.W.;
J. Biol. Chem. 273:12101-12108(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS LYS-457; LYS-466; PRO-474; THR-591; ALA-685; PHE-999 AND THR-1154; Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.
Onate S.A.; Tsai S.Y.; Tsai M.-J.; O'Malley B.W.;
Science 270:1354-1357(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 363-1441 (ISOFORM 1); FUNCTION; INTERACTION WITH ESR1; RXRA; GCCR; PGR AND THRA; VARIANTS LYS-457; LYS-466; PRO-474; THR-591; ALA-685; ALA-794; PHE-999 AND THR-1154;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.