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UniProtKB/Swiss-Prot P51610: Variant p.Ser1164Pro

Host cell factor 1
Gene: HCFC1
Variant information Variant position: help 1164 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Proline (P) at position 1164 (S1164P, p.Ser1164Pro). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to medium size and hydrophobic (P) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.

Sequence information Variant position: help 1164 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 2035 The length of the canonical sequence.
Location on the sequence: help PAVIRISVATGALEAAQGSK S QCQTRQTSATSTTMTVMATG The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.



Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
Chain 2 – 1423 HCF N-terminal chain 6
Chain 2 – 1323 HCF N-terminal chain 5
Chain 2 – 1295 HCF N-terminal chain 4
Chain 1020 – 2035 HCF C-terminal chain 1
Chain 1082 – 2035 HCF C-terminal chain 2
Chain 1111 – 2035 HCF C-terminal chain 3
Repeat 1158 – 1183 HCF repeat 4; degenerate
Alternative sequence 429 – 2035 Missing. In isoform 3.

Literature citations
Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28.
Frattini A.; Faranda S.; Redolfi E.; Zucchi I.; Villa A.; Patrosso M.C.; Strina D.; Susani L.; Vezzoni P.;
Genomics 23:30-35(1994)
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.