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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q96LC7: Variant p.Ala226Val

Sialic acid-binding Ig-like lectin 10
Gene: SIGLEC10
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Variant information Variant position: help 226
Type of variant: help LB/B
Residue change: help From Alanine (A) to Valine (V) at position 226 (A226V, p.Ala226Val).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and hydrophobic (V)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 226
Protein sequence length: help 697
Location on the sequence: help PQDHNTDLTCHVDFSRKGVS A QRTVRLRVAYAPRDLVISIS
Residue conservation: help
Human                         PQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISIS

Mouse                         LQHHDTELTCQLDFSR--MSTQRTVRLRVAYAPRSLAISIF

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 17 – 697 Sialic acid-binding Ig-like lectin 10
Topological domain 17 – 550 Extracellular
Domain 146 – 231 Ig-like C2-type 1
Alternative sequence 146 – 228 Missing. In isoform 9.
Alternative sequence 186 – 697 Missing. In isoform 5.



Literature citations
Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.
Munday J.; Kerr S.; Ni J.; Cornish A.L.; Zhang J.Q.; Nicoll G.; Floyd H.; Mattei M.-G.; Moore P.; Liu D.; Crocker P.R.;
Biochem. J. 355:489-497(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; TISSUE SPECIFICITY; VARIANT VAL-226; Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells.
Li N.; Zhang W.; Wan T.; Zhang J.; Chen T.; Yu Y.; Wang J.; Cao X.;
J. Biol. Chem. 276:28106-28112(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); TISSUE SPECIFICITY; VARIANT VAL-226; Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1.
Kitzig F.; Martinez-Barriocanal A.; Lopez-Botet M.; Sayos J.;
Biochem. Biophys. Res. Commun. 296:355-362(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3); ALTERNATIVE SPLICING (ISOFORMS 4 AND 5); TISSUE SPECIFICITY; VARIANT VAL-226; PHOSPHORYLATION AT TYR-667; MUTAGENESIS OF TYR-667; INTERACTION WITH PTPN6; FUNCTION; Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.; Suzuki Y.; Nishikawa T.; Otsuki T.; Sugiyama T.; Irie R.; Wakamatsu A.; Hayashi K.; Sato H.; Nagai K.; Kimura K.; Makita H.; Sekine M.; Obayashi M.; Nishi T.; Shibahara T.; Tanaka T.; Ishii S.; Yamamoto J.; Saito K.; Kawai Y.; Isono Y.; Nakamura Y.; Nagahari K.; Murakami K.; Yasuda T.; Iwayanagi T.; Wagatsuma M.; Shiratori A.; Sudo H.; Hosoiri T.; Kaku Y.; Kodaira H.; Kondo H.; Sugawara M.; Takahashi M.; Kanda K.; Yokoi T.; Furuya T.; Kikkawa E.; Omura Y.; Abe K.; Kamihara K.; Katsuta N.; Sato K.; Tanikawa M.; Yamazaki M.; Ninomiya K.; Ishibashi T.; Yamashita H.; Murakawa K.; Fujimori K.; Tanai H.; Kimata M.; Watanabe M.; Hiraoka S.; Chiba Y.; Ishida S.; Ono Y.; Takiguchi S.; Watanabe S.; Yosida M.; Hotuta T.; Kusano J.; Kanehori K.; Takahashi-Fujii A.; Hara H.; Tanase T.-O.; Nomura Y.; Togiya S.; Komai F.; Hara R.; Takeuchi K.; Arita M.; Imose N.; Musashino K.; Yuuki H.; Oshima A.; Sasaki N.; Aotsuka S.; Yoshikawa Y.; Matsunawa H.; Ichihara T.; Shiohata N.; Sano S.; Moriya S.; Momiyama H.; Satoh N.; Takami S.; Terashima Y.; Suzuki O.; Nakagawa S.; Senoh A.; Mizoguchi H.; Goto Y.; Shimizu F.; Wakebe H.; Hishigaki H.; Watanabe T.; Sugiyama A.; Takemoto M.; Kawakami B.; Yamazaki M.; Watanabe K.; Kumagai A.; Itakura S.; Fukuzumi Y.; Fujimori Y.; Komiyama M.; Tashiro H.; Tanigami A.; Fujiwara T.; Ono T.; Yamada K.; Fujii Y.; Ozaki K.; Hirao M.; Ohmori Y.; Kawabata A.; Hikiji T.; Kobatake N.; Inagaki H.; Ikema Y.; Okamoto S.; Okitani R.; Kawakami T.; Noguchi S.; Itoh T.; Shigeta K.; Senba T.; Matsumura K.; Nakajima Y.; Mizuno T.; Morinaga M.; Sasaki M.; Togashi T.; Oyama M.; Hata H.; Watanabe M.; Komatsu T.; Mizushima-Sugano J.; Satoh T.; Shirai Y.; Takahashi Y.; Nakagawa K.; Okumura K.; Nagase T.; Nomura N.; Kikuchi H.; Masuho Y.; Yamashita R.; Nakai K.; Yada T.; Nakamura Y.; Ohara O.; Isogai T.; Sugano S.;
Nat. Genet. 36:40-45(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7); VARIANT VAL-226; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT VAL-226;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.