Sequence information
Variant position: 589 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 594 The length of the canonical sequence.
Location on the sequence:
YTGLSSSSARFLSRSIPSLQ
S EYVHY
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human Y-----TGLSSSSARFLSRSIPSLQS EYVHY
Mouse F----PGSLSSSSVRFLSRSIPSLQS
Zebrafish HQRNPPAGLSGLSTRHLSRSIPSLQS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 594
Dual specificity protein phosphatase CDC14A
Modified residue
583 – 583
Phosphoserine
Alternative sequence
192 – 594
Missing. In isoform 4.
Alternative sequence
384 – 594
Missing. In isoform 3.
Alternative sequence
586 – 594
SLQSEYVHY -> VSAQTPPPGPQNPECNFCALPSQPRLPPKKFNSAKEAF. In isoform 2.
Alternative sequence
586 – 594
SLQSEYVHY -> CSCLLLVFRKPFLGSPLLSLPISHL. In isoform 5.
Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLN-345 AND PHE-589;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.