Variant position: 415 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 505 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KDVLIEFYAPWCGHCKNLEP KYKELGEKLSKDPNIVIAKMD
Mouse KDVLIEFYAPWCGHCKNLEP KYKELGEKLSKDPNIVIAKMD
Rat KDVLIEFYAPWCGHCKNLEP KYKELGEKLSKDPNIVIAKMD
Bovine KDVLIEFYAPWCGHCKNLEP KYKELGEKLRKDPNIVIAKMD
Chicken KDVLIEFYAPWCGHCKNLEP KYKELGEKLSKDPNIVIAKMD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 505 Protein disulfide-isomerase A3
343 – 485 Thioredoxin 2
406 – 406 Nucleophile
409 – 409 Nucleophile
407 – 407 Contributes to redox potential value
408 – 408 Contributes to redox potential value
406 – 406 C -> A. No loss of activity. No loss of activity; when associated with A-57.
406 – 406 C -> S. Activity changed to serine protease.
409 – 409 C -> S. Activity changed to serine protease; when associated with S-60.
407 – 422
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.