Variant position: 81 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 906 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GEDESRHDALDTRVRGDLGG P----QLTHVDQASFQVDAFGTSFI
Mouse GEDETQHNQLDTRVRGDPGG P----QLTHVDKASFRVDAFG
Xenopus laevis EDNQTTQGLLSTRVRA--GS PQHQDQLTHVAQASFQIDAFG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
26 – 222
Isolation and tissue specific expression of novel ADAM family from 7q21.1 region.
Wada M.; Torigoe K.; Harada T.; Kuwano M.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5); VARIANT ARG-81;
The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.
Poindexter K.; Nelson N.; DuBose R.F.; Black R.A.; Cerretti D.P.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 40-906 (ISOFORM 1); VARIANT ARG-81;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.