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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O75631: Variant p.Ala154Pro

Uroplakin-3a
Gene: UPK3A
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Variant information Variant position: help 154
Type of variant: help LB/B
Residue change: help From Alanine (A) to Proline (P) at position 154 (A154P, p.Ala154Pro).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and hydrophobic (P)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 154
Protein sequence length: help 287
Location on the sequence: help VRVGANGTCLWDPNFQGLCN A PLSAATEYRFKYVLVNMSTG
Residue conservation: help 
Human                         VRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTG

Mouse                         VRVGNNGTCFWDPNFQGLCNPPLTAATEYRFKYVLVNMSTG

Bovine                        IRVGTNGTCLLDPNFQGLCNPPLSAATEYRFKYVLVNMSSG
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 19 – 287 Uroplakin-3a
Topological domain 19 – 207 Lumenal
Glycosylation 139 – 139 N-linked (GlcNAc...) asparagine
Glycosylation 170 – 170 N-linked (GlcNAc...) asparagine
Alternative sequence 70 – 191 AISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQL -> V. In isoform 2.



Literature citations
Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma.
Yuasa T.; Yoshiki T.; Tanaka T.; Kim C.J.; Isono T.; Okada Y.;
Jpn. J. Cancer Res. 89:879-882(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT PRO-154;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.