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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O60882: Variant p.Ile169Leu

Matrix metalloproteinase-20
Gene: MMP20
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Variant information Variant position: help 169
Type of variant: help LB/B
Residue change: help From Isoleucine (I) to Leucine (L) at position 169 (I169L, p.Ile169Leu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 169
Protein sequence length: help 483
Location on the sequence: help WSSAVPLSFVRINSGEADIM I SFENGDHGDSYPFDGPRGTL
Residue conservation: help 
Human                         WSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTL

Mouse                         WSTAVPLNFVRINSGEADIMISFETGDHGDSYPFDGPRGTL

Pig                           WSSAVPLSFVRVNAGEADIMISFETGDHGDSYPFDGPRGTL

Bovine                        WSSAVPLNFVRINAGEADIMISFETGDHGDSYPFDGPRGTL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 108 – 483 Matrix metalloproteinase-20
Binding site 164 – 164
Binding site 165 – 165
Binding site 166 – 166
Binding site 176 – 176
Binding site 178 – 178
Binding site 183 – 183
Binding site 184 – 184
Binding site 186 – 186
Binding site 188 – 188
Beta strand 166 – 172



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-18; ASN-139; LEU-169; ALA-275 AND ASN-281;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.