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UniProtKB/Swiss-Prot P69905: Variant p.Arg93Trp

Hemoglobin subunit alpha
Gene: HBA2
Chromosomal location: 16p13.3
Variant information

Variant position:  93
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Arginine (R) to Tryptophan (W) at position 93 (R93W, p.Arg93Trp).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to large size and aromatic (W)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In Cemenelum; O(2) affinity up.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  93
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  142
The length of the canonical sequence.

Location on the sequence:   HVDDMPNALSALSDLHAHKL  R VDPVNFKLLSHCLLVTLAAH
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         HVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

Gorilla                       HVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

                              HLDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLACH

Rhesus macaque                HVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

Chimpanzee                    HVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

Mouse                         HLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLASH

Rat                           HVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACH

Pig                           HLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAH

Bovine                        HLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASH

Rabbit                        HLDDLPGALSTLSDLHAHKLRVDPVNFKLLSHCLLVTLANH

Sheep                         HLDDLPGTLSDLSDLHAHKLRVDPVNFKLLSHSLLVTLACH

Cat                           HMDDLPTAMSALSDLHAYKLRVDPVNFKFLSHCLLVTLACH

Horse                         HLDDLPGALSNLSDLHAHKLRVDPVNFKLLSHCLLSTLAVH

Chicken                       HIDDIAGTLSKLSDLHAHKLRVDPVNFKLLGQCFLVVVAIH

Xenopus tropicalis            HLDNIAGCLSKLSDLHAYDLRVDPGNFPLLAHQILVVVAIH

Zebrafish                     KIDDLVGGLAALSELHAFKLRVDPANFKILSHNVIVVIAML

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Metal binding 88 – 88 Iron (heme proximal ligand)
Site 91 – 91 Not glycated
Site 92 – 93 (Microbial infection) Cleavage; by N.americanus apr-2
Site 100 – 100 Not glycated
Modified residue 103 – 103 Phosphoserine
Modified residue 109 – 109 Phosphothreonine
Turn 91 – 93


Literature citations

Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity.
Wajcman H.; Kister J.; M'Rad A.; Soummer A.M.; Galacteros F.;
Ann. Hematol. 68:73-76(1994)
Cited for: VARIANT CEMENELUM TRP-93;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.