Sequence information
Variant position: 93 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
HVDDMPNALSALSDLHAHKL
R VDPVNFKLLSHCLLVTLAAH
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HVDDMPNALSALSDLHAHKLR VDPVNFKLLSHCLLVTLAAH
Gorilla HVDDMPNALSALSDLHAHKLR VDPVNFKLLSHCLLVTLAAH
HLDDLPGALSALSDLHAYKLR VDPVNFKLLSHCLLVTLACH
Rhesus macaque HVDDMPNALSALSDLHAHKLR VDPVNFKLLSHCLLVTLAAH
Chimpanzee HVDDMPNALSALSDLHAHKLR VDPVNFKLLSHCLLVTLAAH
Mouse HLDDLPGALSALSDLHAHKLR VDPVNFKLLSHCLLVTLASH
Rat HVEDLPGALSTLSDLHAHKLR VDPVNFKFLSHCLLVTLACH
Pig HLDDLPGALSALSDLHAHKLR VDPVNFKLLSHCLLVTLAAH
Bovine HLDDLPGALSELSDLHAHKLR VDPVNFKLLSHSLLVTLASH
Rabbit HLDDLPGALSTLSDLHAHKLR VDPVNFKLLSHCLLVTLANH
Sheep HLDDLPGTLSDLSDLHAHKLR VDPVNFKLLSHSLLVTLACH
Cat HMDDLPTAMSALSDLHAYKLR VDPVNFKFLSHCLLVTLACH
Horse HLDDLPGALSNLSDLHAHKLR VDPVNFKLLSHCLLSTLAVH
Chicken HIDDIAGTLSKLSDLHAHKLR VDPVNFKLLGQCFLVVVAIH
Xenopus tropicalis HLDNIAGCLSKLSDLHAYDLR VDPGNFPLLAHQILVVVAIH
Zebrafish KIDDLVGGLAALSELHAFKLR VDPANFKILSHNVIVVIAML
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
88 – 88
Iron (heme proximal ligand)
Site
91 – 91
Not glycated
Site
92 – 93
(Microbial infection) Cleavage; by N.americanus apr-2
Site
100 – 100
Not glycated
Modified residue
103 – 103
Phosphoserine
Modified residue
109 – 109
Phosphothreonine
Turn
91 – 93
Literature citations
Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity.
Wajcman H.; Kister J.; M'Rad A.; Soummer A.M.; Galacteros F.;
Ann. Hematol. 68:73-76(1994)
Cited for: VARIANT CEMENELUM TRP-93;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.