Variant position: 345 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 365 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PEPEPKPSLEPNTSLEREPR PNSSPSPSPGQASETPHPRPS-
Mouse PEP----------------- -----SPSP--ASDDPNPGSS
Rat PSP----------------- -----SPSPGLASDDPNPGSS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 365 Sulfotransferase 2B1
303 – 365 Disordered
348 – 348 Phosphoserine
347 – 347 S -> A. No change in subcellular localization.
348 – 348 S -> D. 10-fold increase in specific activity for DHEA sulfation. 10-fold increase in substrate affinity for DHEA and pregnenolone. No effect on substrate affinity for PAPS. Increases enzyme stability.
348 – 348 S -> G. Abolishes nuclear localization.
352 – 352 S -> G. No change in subcellular localization.
357 – 357 S -> G. No change in subcellular localization.
No reference for the current variant in UniProtKB/Swiss-Prot.
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